Amphotericin B Lipid Complex Injection

General

Pronunciation:
(am foe ter' i sin)

Brand names:

  • Abelcet®
  • Amphotec®

Why Prescribed

Amphotericin B lipid complex injection is used to treat serious, possibly life-threatening fungal infections in people who did not respond or are unable to tolerate conventional amphotericin B therapy. Amphotericin B lipid complex injection is in a class of medications called antifungals. It works by slowing the growth of fungi that cause infection.

How to Use

Amphotericin B lipid complex injection comes as a suspension (liquid) to be injected intravenously (into a vein). It is usually infused (injected slowly) intravenously once daily. The length of your treatment depends on your general health, how you tolerate the medication, and the type of infection you have.

You may experience a reaction while you receive a dose of amphotericin B lipid complex injection, usually happen 1 to 2 hours after starting your infusion. These reactions are usually more common and more severe with the first few doses of amphotericin B lipid complex. Your health care provider may prescribe other medications to decrease these side effects. Tell your doctor immediately if you experience any of these symptoms while you receive amphotericin B lipid complex injection: fever, chills, nausea, vomiting, shortness of breath, breathing problems, chest pain, dizziness, loss of consciousness, or fast, irregular, or pounding heartbeat.

You may receive amphotericin B injection in a hospital or you may use the medication at home. If you will be using amphotericin B lipid complex injection at home, your healthcare provider will show you how to infuse the medication. Be sure that you understand these directions, and ask your healthcare provider if you have any questions. Ask your healthcare provider what to do if you have any problems infusing amphotericin B lipid complex injection.

If your symptoms do not improve or get worse while receiving amphotericin B lipid complex, tell your doctor. If you still have symptoms of infection after you finish amphotericin B lipid complex injection, tell your doctor.

Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient.

Other Uses

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Special Precautions

Before receiving amphotericin B lipid complex injection,

Hypersensitivity

tell your doctor and pharmacist if you are allergic to amphotericin B, any other medications, or any of the ingredients in amphotericin B lipid complex injection. Ask your pharmacist for a list of the ingredients.

Drug Interaction

tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: aminoglycoside antibiotics such as amikacin, gentamicin, or tobramycin (Bethkis, Kitabis Pak, Tobi); antifungals such as clotrimazole, fluconazole (Diflucan), itraconazole (Onmel, Sporanox), ketoconazole (Extina, Nizoral, Xolegel), and miconazole (Oravig, Monistat); medications for the treatment of cancer; corticotropin (H.P. Acthar Gel); cyclosporine (Gengraf, Neoral, Sandimmune); digoxin (Lanoxin); flucytosine (Ancobon); pentamidine (Nebupent, Pentam); steroids taken orally such as dexamethasone, methylprednisolone (Medrol), and prednisone (Rayos); and zidovudine (Retrovir, in Combivir, in Trizivir). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.

tell your doctor if you are receiving leukocyte (white blood cell) transfusions.

Precautions and Contraindications

tell your doctor if you have or have ever had kidney disease.

Pregnancy, Fertility, Lactation

tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while receiving amphotericin B lipid complex injection, call your doctor. Do not breast-feed while receiving amphotericin B complex lipid injection.

Surgery Precautions

if you are having surgery, including dental surgery, tell the doctor or dentist that you are receiving amphotericin B lipid complex injection.

Special Dietary Instructions

Unless your doctor tells you otherwise, continue your normal diet.

Side Effects

Common Side Effects

Amphotericin B lipid complex injection may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • stomach pain or cramping
  • heartburn
  • diarrhea
  • weight loss
  • loss of appetite
  • muscle or joint pain
  • injection site redness or swelling
  • pale skin
  • shortness of breath
  • dizziness
  • headache
  • coldness in the hands and feet

Severe Side Effects

Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately or get emergency medical treatment:

  • rash
  • skin blisters
  • wheezing
  • difficulty breathing
  • itching
  • swelling of the face, throat, tongue, lips, eyes
  • bloody vomit
  • black and tarry stools
  • blood in stool
  • yellowing of the skin or eyes
  • decreased urination

Amphotericin B lipid complex injection may cause other side effects. Call your doctor if you have any unusual problems while receiving this medication.

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Additional Information

Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests during your treatment to check your body's response to amphotericin B lipid complex injection.

Do not let anyone else use your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

This branded product is no longer on the market. Generic alternatives may be available.

Copyright

This report on medications is for your information only, and is not considered individual patient advice. Because of the changing nature of drug information, please consult your physician or pharmacist about specific clinical use.

The American Society of Health-System Pharmacists, Inc. represents that the information provided hereunder was formulated with a reasonable standard of care, and in conformity with professional standards in the field. The American Society of Health-System Pharmacists, Inc. makes no representations or warranties, express or implied, including, but not limited to, any implied warranty of merchantability and/or fitness for a particular purpose, with respect to such information and specifically disclaims all such warranties. Users are advised that decisions regarding drug therapy are complex medical decisions requiring the independent, informed decision of an appropriate health care professional, and the information is provided for informational purposes only. The entire monograph for a drug should be reviewed for a thorough understanding of the drug's actions, uses and side effects. The American Society of Health-System Pharmacists, Inc. does not endorse or recommend the use of any drug. The information is not a substitute for medical care.

AHFS® Patient Medication Information. © Copyright, 2016. The American Society of Health-System Pharmacists, Inc., 7272 Wisconsin Avenue, Bethesda, Maryland. All Rights Reserved. Duplication for commercial use must be authorized by ASHP.

Selected Revisions: May 15, 2016.

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