(a flib' er sept)
Aflibercept injection is used to treat wet age-related macular degeneration (AMD; an ongoing disease of the eye that causes loss of the ability to see straight ahead and may make it more difficult to read, drive, or perform other daily activities). It is also used to treat macular edema after retinal vein occlusion (an eye disease caused by blockage of blood flow from the eye that leads to blurry vision and vision loss), diabetic macular edema (an eye disease caused by diabetes that can lead to vision loss), and diabetic retinopathy (damage to the eyes caused by diabetes). Aflibercept injection is in a class of medications called vascular endothelial growth factor-A (VEGF-A) and placental growth factor (PlGF) antagonists. It works by stopping abnormal blood vessel growth and leakage in the eye(s) that may cause vision loss in people with certain eye conditions.
How to Use
Aflibercept injection comes as a solution (liquid) to be injected into the eye by a doctor. It is usually given in a doctor's office. Your doctor will give you injections on a schedule that is best for you and your condition.
Before you receive an aflibercept injection, your doctor will clean your eye to prevent infection and numb your eye to reduce discomfort during the injection. After your injection, your doctor will need to examine your eyes before you leave the office.
Aflibercept injection controls certain eye conditions, but does not cure them. Your doctor will watch you carefully to see how well aflibercept injection works for you. Talk to your doctor about how long you should continue treatment with aflibercept injection.
This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.
Before receiving aflibercept injection,
tell your doctor and pharmacist if you are allergic to aflibercept, any other medications, or any of the ingredients in aflibercept injection. Ask your pharmacist for a list of the ingredients.
tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take.
Precautions and Contraindications
tell your doctor if you have an infection or swelling in or around the eye. Your doctor will probably tell you that you should not receive aflibercept injection.
Pregnancy, Fertility, Lactation
tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while receiving aflibercept injection, call your doctor.
you should know that aflibercept injection may cause vision problems. Do not drive a car or operate machinery until you know how this medication affects you.
Special Dietary Instructions
Unless your doctor tells you otherwise, continue your normal diet.
Forgot a Dose
If you miss an appointment to receive aflibercept injection, call your doctor as soon as possible.
Common Side Effects
Aflibercept injection may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
- feeling that something is in your eye
- teary eyes
Severe Side Effects
Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately or get emergency medical treatment:
- eye redness or pain
- eye sensitivity to light
- decrease or changes in vision
- bleeding in or around the eye
- seeing ''floaters'' or small specks
- injection site pain
- seeing flashes of lights
- chest pain
- shortness of breath
- slow or difficult speech
- dizziness or faintness
- weakness or numbness of an arm or leg
- difficulty breathing or swallowing
Aflibercept injection may cause other side effects. Call your doctor if you have any unusual problems while receiving this medication.
If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).
In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.
Keep all appointments with your doctor.
Ask your pharmacist any questions you have about aflibercept injection.
It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.
This report on medications is for your information only, and is not considered individual patient advice. Because of the changing nature of drug information, please consult your physician or pharmacist about specific clinical use.
The American Society of Health-System Pharmacists, Inc. represents that the information provided hereunder was formulated with a reasonable standard of care, and in conformity with professional standards in the field. The American Society of Health-System Pharmacists, Inc. makes no representations or warranties, express or implied, including, but not limited to, any implied warranty of merchantability and/or fitness for a particular purpose, with respect to such information and specifically disclaims all such warranties. Users are advised that decisions regarding drug therapy are complex medical decisions requiring the independent, informed decision of an appropriate health care professional, and the information is provided for informational purposes only. The entire monograph for a drug should be reviewed for a thorough understanding of the drug's actions, uses and side effects. The American Society of Health-System Pharmacists, Inc. does not endorse or recommend the use of any drug. The information is not a substitute for medical care.
AHFS® Patient Medication Information. © Copyright, 2017. The American Society of Health-System Pharmacists, Inc., 7272 Wisconsin Avenue, Bethesda, Maryland. All Rights Reserved. Duplication for commercial use must be authorized by ASHP.
Selected Revisions: February 15, 2017.