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Midodrine may cause supine hypertension (high blood pressure that occurs when lying flat on your back). This medication should only be used by people whose low blood pressure severely limits their ability to perform daily activities and who could not be treated successfully with other therapies. Tell your doctor if you have or have ever had high blood pressure. Tell your doctor and pharmacist if you are taking dihydroergotamine (DHE, Migranal). Also tell your doctor and pharmacist what other prescription and nonprescription medications you are taking, including ephedrine, phenylephrine, phenylpropanolamine, and pseudoephedrine. Many nonprescription products contain these medications (e.g. diet pills and medications for cough and colds), so check labels carefully. If you experience any of the following symptoms, stop taking midodrine and call your doctor immediately: awareness of your heartbeat, pounding in your ears, headache, or blurred vision. After beginning treatment, your doctor may tell you to continue taking midodrine only if you have significant improvement in your symptoms. Talk to your doctor about how you are feeling while taking this medication.
Keep all appointments with your doctor. You should have your blood pressure checked in the standing and lying flat positions before starting treatment and regularly while you are taking midodrine.
Talk to your doctor about the risks of taking midodrine.